P2RX7 inhibitor suppresses exosome secretion and disease phenotype in P301S tau transgenic mice
Abstract
The P2RX7 receptor is an ATP-gated ion channel that plays important roles in inflammation and cell death. This study investigates the therapeutic potential of P2RX7 inhibition in P301S tau transgenic mice, a model of tauopathy. We demonstrate that P2RX7 inhibitor treatment suppresses exosome secretion and ameliorates disease phenotypes, including tau pathology and neuroinflammation. The findings suggest that P2RX7 represents a promising therapeutic target for tauopathies and that modulation of exosome secretion may be an important mechanism of action. This work provides preclinical evidence for P2RX7 inhibition as a potential treatment strategy for Alzheimer’s disease and related tauopathies.
This study provides important preclinical evidence for P2RX7 inhibition as a therapeutic strategy for tauopathies. The demonstration that P2RX7 inhibitors can suppress exosome secretion and improve disease phenotypes opens new avenues for drug development in neurodegenerative diseases.
Lawrence Jianqiao Hu
Doctoral Candidate in Neuroscience
Ph.D. Ambassador, UW Medicine
My research interests include…