Human neural cell type-specific extracellular vesicle proteome defines disease-related molecules associated with activated astrocytes in Alzheimer's disease brain
Abstract
Extracellular vesicles (EVs) are membrane-bound particles released by cells that carry molecular information and play crucial roles in intercellular communication. This study presents a comprehensive proteomic analysis of human neural cell type-specific EVs, revealing disease-related molecules associated with activated astrocytes in Alzheimer’s disease brain. Using advanced mass spectrometry techniques, we identified cell type-specific EV protein signatures and characterized how these profiles change in Alzheimer’s disease, providing new insights into neuroinflammation and potential biomarkers for disease progression.
This study provides important insights into the role of extracellular vesicles in Alzheimer’s disease pathology, particularly focusing on astrocyte activation and neuroinflammation. The cell type-specific proteomic profiles identified here may serve as valuable biomarkers for disease progression and therapeutic targets.
Lawrence Jianqiao Hu
Doctoral Candidate in Neuroscience
Ph.D. Ambassador, UW Medicine
My research interests include…