Enrichment of Phosphorylated Tau (Thr181) and Functionally Interacting Molecules in Chronic Traumatic Encephalopathy Brain-derived Extracellular Vesicles
Abstract
Chronic traumatic encephalopathy (CTE) is a progressive neurodegenerative disease associated with repetitive brain trauma. This study investigates the enrichment of phosphorylated tau (Thr181) and functionally interacting molecules in brain-derived extracellular vesicles from CTE patients. Using advanced proteomic approaches, we identified specific molecular signatures in extracellular vesicles that may serve as biomarkers for CTE diagnosis and provide insights into disease mechanisms. The findings suggest that extracellular vesicles play a crucial role in the propagation of tau pathology in CTE and related neurodegenerative diseases.
This research contributes to our understanding of chronic traumatic encephalopathy and the role of extracellular vesicles in neurodegenerative disease progression. The identification of specific molecular signatures may lead to improved diagnostic tools and therapeutic targets.
Lawrence Jianqiao Hu
Doctoral Candidate in Neuroscience
Ph.D. Ambassador, UW Medicine
My research interests include…