Enrichment of Neurodegenerative Microglia Signature in Brain-Derived Extracellular Vesicles Isolated from Alzheimer's Disease Mouse Models
Abstract
Microglia, the brain’s resident immune cells, undergo significant changes during neurodegeneration, adopting disease-associated phenotypes. This study examines the enrichment of neurodegenerative microglia signatures in brain-derived extracellular vesicles isolated from Alzheimer’s disease mouse models. Using quantitative proteomics, we identified specific protein signatures associated with activated microglia and demonstrated how these signatures are reflected in extracellular vesicles. These findings provide insights into microglial activation in Alzheimer’s disease and suggest that extracellular vesicles may serve as biomarkers for neuroinflammation and disease progression.
This research advances our understanding of microglial activation in Alzheimer’s disease and demonstrates the utility of extracellular vesicles as windows into brain pathology. The identified protein signatures may serve as valuable biomarkers for disease monitoring and therapeutic development.
Lawrence Jianqiao Hu
Doctoral Candidate in Neuroscience
Ph.D. Ambassador, UW Medicine
My research interests include…