Alzheimer's disease

Human neural cell type-specific extracellular vesicle proteome defines disease-related molecules associated with activated astrocytes in Alzheimer's disease brain
Comprehensive proteomic analysis of human neural cell type-specific extracellular vesicles reveals disease-related molecules associated with activated astrocytes in Alzheimer’s disease brain.
Yang You, Satoshi Muraoka, Mark P. Jedrychowski, Lawrence Jianqiao Hu, Amanda K. McQuade, Tracy Young-Pearse, Roshanak Aslebagh, Scott A. Shaffer, Steven P. Gygi, Mathew Blurton-Jones, Wayne W. Poon, Tsuneya Ikezu
DOI Journal Link
Human neural cell type-specific extracellular vesicle proteome defines disease-related molecules associated with activated astrocytes in Alzheimer's disease brain
Comprehensive proteomic analysis of human neural cell type-specific extracellular vesicles reveals disease-related molecules associated with activated astrocytes in Alzheimer’s disease brain.
Yang You, Satoshi Muraoka, Mark P. Jedrychowski, Lawrence Jianqiao Hu, Amanda K. McQuade, Tracy Young-Pearse, Roshanak Aslebagh, Scott A. Shaffer, Steven P. Gygi, Mathew Blurton-Jones, Wayne W. Poon, Tsuneya Ikezu
DOI Journal Link
Enrichment of Neurodegenerative Microglia Signature in Brain-Derived Extracellular Vesicles Isolated from Alzheimer's Disease Mouse Models
Proteomic analysis of brain-derived extracellular vesicles from Alzheimer’s disease mouse models reveals enrichment of neurodegenerative microglia signatures, providing insights into neuroinflammation.
Satoshi Muraoka, Mark P. Jedrychowski, Naotoshi Iwahara, Mohammad Abdullah, Kristen D. Onos, Kelly J. Keezer, Lawrence Jianqiao Hu, Seiko Ikezu, Gareth R. Howell, Steven P. Gygi, Tsuneya Ikezu
DOI Journal Link
Alzheimer's disease brain-derived extracellular vesicles spread tau pathology in interneurons
This study demonstrates that Alzheimer’s disease brain-derived extracellular vesicles can spread tau pathology to interneurons, revealing new mechanisms of disease progression.
Zhi Ruan, Dhruba Pathak, Srinidhi Venkatesan Kalavai, Asuka Yoshii-Kitahara, Satoshi Muraoka, Nemil Bhatt, Kayo Takamatsu-Yukawa, Lawrence Jianqiao Hu, Yuzhi Wang, Samuel Hersh, Maria Ericsson, Santhi Gorantla, Howard E. Gendelman, Rakez Kayed, Seiko Ikezu, Jennifer I. Luebke, Tsuneya Ikezu
DOI Journal Link