Mouse models

Enrichment of Neurodegenerative Microglia Signature in Brain-Derived Extracellular Vesicles Isolated from Alzheimer's Disease Mouse Models
Proteomic analysis of brain-derived extracellular vesicles from Alzheimer’s disease mouse models reveals enrichment of neurodegenerative microglia signatures, providing insights into neuroinflammation.
Satoshi Muraoka, Mark P. Jedrychowski, Naotoshi Iwahara, Mohammad Abdullah, Kristen D. Onos, Kelly J. Keezer, Lawrence Jianqiao Hu, Seiko Ikezu, Gareth R. Howell, Steven P. Gygi, Tsuneya Ikezu
DOI Journal Link
P2RX7 inhibitor suppresses exosome secretion and disease phenotype in P301S tau transgenic mice
P2RX7 inhibitor treatment suppresses exosome secretion and ameliorates disease phenotypes in P301S tau transgenic mice, suggesting a promising therapeutic approach for tauopathies.
Zhi Ruan, Jean-Christophe Delpech, Srinidhi Venkatesan Kalavai, Alicia A. Van Enoo, Lawrence Jianqiao Hu, Seiko Ikezu, Tsuneya Ikezu
DOI Journal Link