Tau pathology

Enrichment of Phosphorylated Tau (Thr181) and Functionally Interacting Molecules in Chronic Traumatic Encephalopathy Brain-derived Extracellular Vesicles
Investigation of phosphorylated tau and associated molecules in brain-derived extracellular vesicles from CTE patients reveals potential biomarkers and disease mechanisms.
Satoshi Muraoka, Weiwei Lin, Kayo Takamatsu-Yukawa, Lawrence Jianqiao Hu, Seiko Ikezu, Michael A. DeTure, Dennis W. Dickson, Andrew Emili, Tsuneya Ikezu
DOI Journal Link
Alzheimer's disease brain-derived extracellular vesicles spread tau pathology in interneurons
This study demonstrates that Alzheimer’s disease brain-derived extracellular vesicles can spread tau pathology to interneurons, revealing new mechanisms of disease progression.
Zhi Ruan, Dhruba Pathak, Srinidhi Venkatesan Kalavai, Asuka Yoshii-Kitahara, Satoshi Muraoka, Nemil Bhatt, Kayo Takamatsu-Yukawa, Lawrence Jianqiao Hu, Yuzhi Wang, Samuel Hersh, Maria Ericsson, Santhi Gorantla, Howard E. Gendelman, Rakez Kayed, Seiko Ikezu, Jennifer I. Luebke, Tsuneya Ikezu
DOI Journal Link